Longterm treatment of chronic depressed patients (LAC)

Summary in English



The treatment of depression provides both a major challenge and opportunity to psychoanalysis. More than 20% of patients with major depression do not respond to antidepressant medication and one-third who initially responded to medication relapse within a year. If we take depression currently ranking fourth among the 10 leading causes of the global burden of disease, it is predicted that by the year 2020, it will have jumped to second place (WHO). The LAC depression study examines the effectiveness of psychotherapeutic longterm  treatments of chronically depressed patients and compares psychoanalytic with cognitive-behavioral treatments. The study has started in 2007 and is funded by the DGPT, the Heidhof Foundation and the IPA Research Advisory Board. It is a multicenter study with centers in Middle and Northern Germany and an Statistics and Methodology Center that independently monitors data collection and analyses. The LAC Depression Study is the first, as far as we know, prospective study that compares these two treatments and also examines the influence of randomized and preferred treatments. The study design combines a naturalistic and experimental approach. A combination of clinical and extraclinical research methods and instruments allows us to meet the requirements of treatment comparison studies as well as the criteria of the Scientific Counsil of Psychotherapy for randomized conrolled trial studies. We follow a comprehensive procedure of data collection and accompany patients for five years. Maintaining the depth of modern psychoanalytic knowledge about depression also poses challenges for clinical, conceptual and empirical forms of research. Clinical research is still the heart of psychoanalytic research and refers to an understanding of unconscious processes and biographic, idiosyncratic uniqueness, i.e., on the analysis of the complex intertwinement of various factors in the micro world of a patient.




Prof. Marianne Leuzinger-Bohleber
Sekretariat: Renate Stebahne
Telefon 069 971204-149
E-Mail m.leuzinger-bohleber

PD. Dr. Ulrich Bahrke
Telefon 069 971204-130
E-Mail bahrke

Telefax 069 971204-150