Forschungsfeld 3

Frankfurt fMRI/EEG depression-study

Project-title: Frankfurt fMRI/EEG depression-study

Project-type: Psychotherapy-effectivity neuropsychoanalytic research

Acronym: FRED

Duration: 2007 - ongoing

Short description

The Frankfurt fMRI/EEG Depression-Study (FRED) aims at investigating effects of medical or psychotherapeutic interventions on brain functioning via fMRI (functional magnetic resonance imaging) and EEG (electroencephalogram). In cooperation with the LAC-study (-> Longterm therapies with chronic depressed patients – LAC) chronic depressed patients are scrutinized neuro-physiologically. The Operationalized psychodynamic diagnostic (OPD)-Interviews conducted in the LAC-study are used to create a compatible, patient specific stimulus for the fMRI-part of the FRED-study. The OPD (Axis II) enables us to ascertain repetitive dysfunctional relationships and formulate them into individual core-conflictual sentences and present them visually during the fMRI-session. The thus activated brain-activities and brain-areas are captured and surveyed at three different measurement-points in the course of therapy. Furthermore these brain-activities are contrasted at each time-point with brain-activities stimulated by a general (traffic) stimulus in order to control for individual conflictuous stimulus-activation. We expect a change in brain-reactions in the course of therapy.
In this part of the FRED-study (fMRI-leg) we also investigate changes in brain-activation in response to an individual dream-word-stimulus seized from a significant dream reported to us by the patient in a dream-interview. From this dream 30 words are taken and presented in the fMRI-session visually. By contrasting the brain-activation-patterns elicited by individual dream-words with reactions to stimulus-words taken from “an-all-purpose”-story with no relation to the patient, we are able to document for one areas of the brain assumingly specific to dreams, and for the other changes occurring in the course of therapy.

In a second part of the FRED-study (EEG-leg) we intend to investigate sleep-patterns and dreams of the patients using EEG. Sleep-patterns are elicited in night-sessions at the sleep-laboratory of our cooperation Partner at the sleep-medical center of the Hospital Hofheim (Kliniken des Main-Tanus-Kreises GmbH Medizinische Klinik III, Krankenhaus Hofheim Schlafmedizinisches Zentrum, see Dreams and their changes in the course of therapy are investigated in this part of the study as well. REM-dreams are being elicited during the night-sessions in the sleep-laboratory as well as morning-dreams. These are then evaluated content-analytically according to the dream-generating-model of U. Moser.

The project is funded by the foundation “Hope for depression” and the Research Advisory Board of the IPA.

In cooperation with the Research Team of LAC
Prof. Dr. Martin Hautzinger, Professor for Cognitive Behavioral Therapy (Eberhard Karls University Tuebingen); Prof. Dr. Manfred Beutel, (Justus-Liebig-University Giessen); Prof. Dr. Ulrich Stuhr (University of Hamburg), Dr. Wolfram Keller (FU Berlin).

In cooperation with the Research Team of the Hanse Neuro-Psychoanalysis Study (HNPS)
Dr. Anna Buchheim (University of Ulm); Prof. Dr. Manfred Cierpka (University of Heidelberg); Prof. Dr. Thomas Münte (Otto-von Guericke University Magdeburg); ); Prof. Dr. Horst Kächele, (University of Ulm); Prof. Dr. Gerhard Roth (Hanse-Wissenschaftskolleg University Bremen).

In cooperation with the Schlafmedizinisches Zentrum des Krankenhaus Hofheim
Prof. Dr. med. Dr. h.c., Stephan Volk, Uwe Fremder, Dipl.-Psych. Markus Specht (somnologist).



Prof. Dr. Marianne Leuzinger-Bohleber
Telefon +49 (0)69 9711204-147
Telefax +49 (0)69 971204-150
E-Mail m.leuzinger

Dr. Tamara Fischmann
Telefon +49 (0)69 971204-136
Telefax +49 (0)69 971204-150
E-Mail dr.fischmann